Villanueva is a Spanish surname. Notable people with the surname include:
Alejandro Villanueva (footballer) (1908–1944), Peruvian football (soccer) player
Alejandro Villanueva (American football) (born 1988), American Football Player for Pittsburgh Steelers
Alex Villanueva, American law enforcement officer, Los Angeles County sheriff since 2018
Alex Villanueva (soccer) (born 2002), American soccer player
Anthony Villanueva (1945–2014), Filipino boxer, represented Philippines in Olympics
Antonio Villanueva (born 1940), Mexican runner
Armando Villanueva (1915–2013), Peruvian politician, full name Armando Villanueva del Campo
Carlos Villanueva (baseball) (born 1983), Dominican professional baseball player in USA
Carlos Villanueva (footballer) (born 1986), Chilean football (soccer) player
Carlos Raúl Villanueva (1900–1975), Venezuelan architect
Cesar L. Villanueva, Philippine attorney and professor
Charlie Villanueva (born 1984), Dominican-American basketball player for the NBA
Christian Villanueva (born 1991), Mexican professional baseball player
Danny Villanueva (1937–2015), American football kicker for the NFL
Darío Villanueva, Spanish literary critic
Eddie Villanueva (Eduardo Villanueva, born 1946), religious and political figure in the Philippines
Eduar Villanueva (born 1984), Venezuelan Olympic middle distance runner
Edgar David Villanueva, Peruvian congressman
Enrico Villanueva, Filipino professional basketball player in the Philippines
Héctor Villanueva (born 1964), Puerto Rican professional baseball player in USA
Idalis Villanueva, American engineering educator from Puerto Rico
José Villanueva, amateur boxer from the Philippines
Joaquín Lorenzo Villanueva, Spanish priest, historian and writer.
José Luis Villanueva (born 1981), Chilean football (soccer) player
Juan de Villanueva (1739–1811), Spanish neoclassical architect
Karen Villanueva (born 1998), Mexican rhythmic gymnast
Lord Villanueva (born 1975), Filipino associate justice of the Sandiganbayan
Mariana Villanueva (born 1964), Mexican composer
Matthías Villanueva (born 1993), Chilean football (soccer) player
Muriel Villanueva i Perarnau (born 1976), Spanish writer
Nathanael Villanueva (born 1995), Filipino football (soccer) player
Raul Villanueva (born 1963), Filipino associate justice of the Supreme Court
Rene Villanueva (1954–2007), Filipino author published in the Philippines
Ron Villanueva (born 1970), American politician serving in the Virginia House of Delegates
Sal Villanueva, American record producer (1999–2007)
Vicente Villanueva (1924–2014), Peruvian footballer