The Big Empty is a 2005 short film starring Selma Blair about a woman with an unusual condition that baffles scientists and laymen alike. It was written, directed and produced by Lisa Chang and Newton Thomas Sigel. It is based on the short story The Specialist, by Alison Smith. It was executive produced by George Clooney and Steven Soderbergh.

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Not who you're looking for? Others named The Big Empty: 2003 film by Steve Anderson · episode of The Expanse (S1 E2)