Smiltsena was the niece of Byzantine Emperor Michael VIII Palaiologos, and empress-consort (tsaritsa) of Tsar Smilets of Bulgaria. Empress consort of Bulgaria Smiltsena was the daughter of sebastocrator Constantine Palaiologos, who was a half-brother of Emperor Michael VIII Palaiologos, and his wife Irene Komnene Laskarina Branaina. In the histories she was called just Smiltsena, without a name being given. Smilets ascended the throne of Bulgaria in 1292 and the new tsaritsa moved from her husband's provincial residence into the royal palace in Tarnovo.

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