Sison is a surname found in the Philippines. Notable people with this surname include:
Jose Maria Sison (1939–2022), founder of the Communist Party of the Philippines in 1968 and the New People's Army guerrilla group in 1969
Connie Sison (born 1975), Filipina journalist
Boyet Sison (1963–2022), Filipino journalist and sports commentator
Frederick Samuel Sison (died 1891) co-owner Pirie Street Brewery in South Australia
Marco Sison (born 1957), Filipino actor and singer
Teófilo Sison (1880–1975), Filipino politician