Santa Cruz is a county in southern Arizona, United States. As of the 2020 census, the population was 47,669. The county seat is Nogales. The county was established in 1899. It borders Pima County to the north and west, Cochise County to the east, and the Mexican state of Sonora to the south.

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Not who you're looking for? Others named Santa Cruz County: county in California, United States

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