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The International Prospective Register of Systematic Reviews, better known as PROSPERO, is an open access online database of systematic review protocols on a wide range of topics. While it was initially restricted to medicine, , it also accepts protocols in criminology, social care, education and international development, as long as there is a health-related outcome. Researchers can choose to have their reviews prospectively registered with PROSPERO. The database is produced by the Centre for Reviews and Dissemination at the University of York in England, and it is funded by the National Institute for Health Research. Registration of systematic reviews in the database has been supported by PLoS Medicine, BioMed Central, the EQUATOR Network, and BMJ editor-in-chief Fiona Godlee, among others.
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