Poo a surname. Notable people with the surname include:
Ai-jen Poo (born 1974), American labor activist
Fernão do Pó, 15th-century Portuguese navigator and explorer also known as Fernando Poo
Karin Sham Poo (born 1943), Norwegian banker and diplomat
Mu-ming Poo (born 1948), American neuroscientist
Murdaya Poo (1946–2025), Indonesian businessman and politician
Sam Poo (died 1865), Chinese bushranger in Australia, hanged for murder