Monaco is a surname. Notable people with the surname include:
Juan Mónaco (born 1984), Argentine tennis player
Kara Monaco (born 1983), 2006 Playmate of the Year
Kelly Monaco (born 1976), American model and actress
Lorenzo Monaco (c. 1370 –c. 1425), Italian painter
Mario del Monaco (1915–1982), Italian tenor
Ron Monaco (born 1963), American football player