Madame Web (Cassandra Webb) is a fictional character appearing in American comic books published by Marvel Comics. She first appeared in The Amazing Spider-Man #210, published November 1980, and was created by writer Denny O'Neil and artist John Romita Jr. She is usually depicted as a supporting character in the Spider-Man comic book series, where she appears as an elderly woman with myasthenia gravis, connected to a life support system resembling a spiderweb.

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