Machuca is a Spanish and Portuguese surname. Notable people with the surname include:
Alexis Machuca (born 1990), Argentine footballer
Anggello Machuca (born 1984), Paraguayan footballer
Brian Machuca (born 1995), Argentine footballer
Elías Machuca (born 2003), Argentine footballer
Imanol Machuca (born 2000), Argentine footballer
Juan Machuca (born 1951), Chilean footballer
Linda Machuca (politician), Ecuadorian politician and diplomat
Linda Machuca (born 2001), Argentine freestyle wrestler
Manuel Machuca (1924–1985), Chilean footballer
Pedro Machuca (c. 1490–1550), Spanish architect
Santiago Machuca (1929–2024), Puerto Rican sport shooter