Hermosillo is a Spanish surname. Notable people with the surname include:
Carlos Hermosillo (born 1964), Mexican footballer
Carmen Hermosillo (died 2008), American writer and poet
Jaime Humberto Hermosillo (1942–2020), Mexican film director
Mayra Hermosillo (born 1987), Mexican actress and filmmaker
Michael Hermosillo (born 1995), American baseball outfielder
Víctor Hermosillo y Celada (born 1939), Mexican politician