Splice

Splice is a 2009 science fiction horror film directed by Vincenzo Natali and starring Adrien Brody, Sarah Polley, and Delphine Chanéac. The story concerns experiments in genetic engineering being done by a young scientific couple, who attempt to introduce human DNA into their work of splicing animal genes resulting in the creation of a human–animal hybrid. Guillermo del Toro, Don Murphy, and Joel Silver are the executive producers of this film. Theatrically released on June 4, 2010, the film received generally positive reviews from critics but was commercially unsuccessful, and grossed just $27.1 million against a $30 million production budget. Plot Genetic engineers Clive Nicoli and Elsa Kast hope to achieve fame by splicing animal DNA to create hybrids for medical use at the company N.E.R.D. (Nucleic Exchange Research and Development). Their work has yielded Fred and Ginger, two large vermiform creatures intended as mates for each other. After successfully mating them, Clive and Elsa plan to create a revolutionary human–animal hybrid. Their employers Joan Chorot and William Barlow forbid this and order them to focus on identifying and extracting proteins from Fred and Ginger for drug production. However, Clive and Elsa follow their plans in secret and develop a viable prepubescent female creature. Although they planned to terminate before the hybrid reached full term, Elsa persuades Clive to let it live. The hybrid physically ages much faster than humans and mentally develops like a human child. After it spells out NERD with toys after seeing the acronym on Elsa's shirt, Elsa names it "Dren". Clive’s brother Gavin discovers Dren but flees after she jumps on him. Elsa notices Dren has a fever and tries to cool her in an industrial-sized sink of cold water. Clive holds Dren underwater. This forces Dren to use her gills, revealing she is amphibious. Elsa forms a motherly bond with Dren. Meanwhile, Elsa and Clive neglect their work with Fred and Ginger. At a publicized presentation, Fred and Ginger fight and kill each other. Ginger had spontaneously changed into a male, but Elsa and Clive failed to notice as they were focused on Dren.