A new protocol outlines an umbrella review to identify nutrients and bioactive components that may support brain health across the life course, signaling a shift from deficiency-based goals to evidence-based, population-level dietary recommendations. Across sources, everyday foods—fatty fish, leafy greens, berries, nuts, and flaxseed oil—are linked to brain health, though no single superfood exists, and findings range from animal studies on tomato lycopene affecting dopamine signaling to calls for clinical trials to establish optimal dosages.