Topic

Selutaront

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Overview

Selutaront is a trace amine-associated receptor 1 (TAAR1) agonist which is being investigated for the potential treatment of schizophrenia. It is a highly selective, low-potency, high-efficacy partial agonist of the human TAAR1 (EC50Tooltip half-maximal effective concentration = 2,330 nM; EmaxTooltip maximal efficacy = 83%). The drug shows antipsychotic-like effects in rodents, such as antagonism of dizocilpine (MK-801)-induced hyperlocomotion, without affecting spontaneous locomotor activity when given by itself. The chemical synthesis of selutaront has been described. Selutaront was first described in the scientific literature by Jianzhao Zhang and colleagues in 2026.

From Wikipedia (CC BY-SA 4.0).

Selutaront is a trace amine-associated receptor 1 (TAAR1) agonist which is being investigated for the potential treatment of schizophrenia. It is a highly selective, low-potency, high-efficacy partial agonist of the human TAAR1 (EC50Tooltip half-maximal effective concentration = 2,330 nM; EmaxTooltip maximal efficacy = 83%). The drug shows antipsychotic-like effects in rodents, such as antagonism of dizocilpine (MK-801)-induced hyperlocomotion, without affecting spontaneous locomotor activity when given by itself. The chemical synthesis of selutaront has been described. Selutaront was first described in the scientific literature by Jianzhao Zhang and colleagues in 2026.

Selutaront across IJR

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