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Luzerne County is a home rule county in the Commonwealth of Pennsylvania. According to the United States Census Bureau, the county has a total area of 906 square miles (2,350 km2), of which 890 square miles (2,300 km2) is land and 16 square miles (41 km2) is water. It is Northeastern Pennsylvania's second-largest county by total area. As of the 2020 census, the population was 325,594, making it the most populous county in the northeastern part of the state. The county also features the largest economy in Northeastern Pennsylvania, generating a GDP of $20.58 billion.