Frame is a surname. Notable people with the surname include:
Billy Frame (1912–1992), Scottish footballer
Bobby Frame (1959–2025), American politician in Oklahoma
Elizabeth Frame, Canadian writer and historian
Esther G. Frame (1840–1920), American Quaker minister and evangelist
Fred Frame (1894–1962), American race car driver
Janet Frame (1924–2004), New Zealand writer
John Frame (disambiguation), several people
Linley Frame (born 1971), Australian swimmer
Margaret Frame (1903–1985), Canadian painter
Margaret Frame, British biologist
Pete Frame (born 1942), English music journalist
Peter Frame (1957–2018), American ballet dancer
Roddy Frame (born 1964), Scottish singer-songwriter and musician (Aztec Camera)
Tom Frame (1931–2006), British comic letterer
Tom Frame (born 1962), Australian Anglican Bishop
William Frame (1848–1906), English architect
William Frame (cricketer) (1932–1965), New Zealand cricketer and murder-suicide perpetrator
Willie Frame (fl. 1920s), Scottish footballer for Clyde, Motherwell and Linfield
Willie Frame (curler), Scottish curler, European champion
Fictional characters
Alice Frame and Steve Frame, on the soap opera Another World