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Esprolol, also known as (S)-ACC-9369, is a beta blocker which was under development for the treatment of angina pectoris, anxiety disorders, and migraine. It is taken sublingually and has a rapid onset of action, short time to peak, and short duration. The drug is a prodrug of amoxolol, which is formed from esprolol via esterase enzymes. It is a selective β1-adrenergic receptor antagonist. Esprolol was under development by Selectus Pharmaceuticals. It reached phase 2 clinical trials for all indications prior to the discontinuation of its development in 2001.