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American Cruise Lines is the largest river and small-ship cruise line in the United States with its headquarters in Guilford, Connecticut. The line has 30 small U.S.-flagged cruise ships that cruise along the Eastern Seaboard, the Hudson River, the Chesapeake Bay, the Great Lakes, and the Western Seaboard as well as the Mississippi, Ohio, Cumberland, Arkansas, and Tennessee rivers and the Columbia-Snake river system in the United States.
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