Benadryl (diphenhydramine) dosing depends on age, weight, and the specific formulation. For adults and children 12 years and older, the typical dose is 25–50 mg every 4–6 hours, not to exceed 300 mg in 24 hours. Children ages 6–11 years usually take 12.5–25 mg every 4–6 hours, with a 150 mg daily maximum. For children under 6, dosing must be determined by a healthcare provider based on weight.
These recommendations apply to over-the-counter diphenhydramine products. Always check the label on your specific product, as concentrations vary (tablets, capsules, and liquids differ). Never exceed the maximum daily dose listed on the package or recommended by your doctor.
For severe allergic reactions—especially those involving difficulty breathing, throat swelling, severe swelling of the face or lips, or signs of anaphylaxis—seek emergency medical help immediately rather than relying solely on Benadryl. Epinephrine (via an EpiPen) is the first-line treatment for severe reactions, not antihistamines.
If you're unsure about the appropriate dose for your situation, age, weight, or other medications you take, consult a pharmacist or healthcare provider before taking Benadryl. Certain conditions and drug interactions can affect safe dosing. Keep in mind that Benadryl causes drowsiness in many people and can impair alertness—plan accordingly if you need to drive or operate machinery.