Wellbutrin (bupropion) can cause nervousness and anxiety in some people, particularly during the first few weeks of treatment or when doses are increased. This side effect occurs because bupropion is a norepinephrine-dopamine reuptake inhibitor that increases activity of stimulating neurotransmitters in the brain, which can feel activating or jittery for certain individuals.
Common nervous or anxiety-related side effects reported include restlessness, tremors, agitation, and insomnia. These effects tend to be dose-dependent—they're more likely at higher doses and often diminish as the body adjusts over 2–4 weeks. Some people experience no nervousness at all, while others find it bothersome enough to warrant dose adjustments or discontinuation.
Factors affecting whether nervousness occurs include individual brain chemistry, baseline anxiety levels, starting dose, and how quickly doses are increased. People with existing anxiety disorders may be more susceptible. Conversely, some patients take Wellbutrin specifically because its activating properties help counteract depression-related fatigue and low motivation.
If nervousness develops, discussing it with your prescriber is important—they may lower the dose, adjust timing of administration, slow the titration schedule, or recommend supportive strategies like reducing caffeine. In some cases, additional medication like a beta-blocker or anxiety medication may be used temporarily. Wellbutrin isn't right for everyone, but nervousness during early treatment doesn't necessarily mean it won't work well long-term once your system adjusts.