No, you do not win any money with just one number on Mega Millions. The lottery requires matching a minimum of the Mega Ball alone to win a prize, which awards $2—matching your ticket's Mega Ball number against the drawn Mega Ball. To win meaningful amounts, you need to match at least one regular number along with the Mega Ball. The prize structure requires combinations: matching just one regular number without the Mega Ball wins nothing. The smallest prize that involves regular numbers is $3, earned by matching one regular number and the Mega Ball together. Prizes escalate significantly for matching more numbers—matching two numbers with the Mega Ball yields $5, and the jackpot requires all five regular numbers plus the Mega Ball. The Mega Ball is weighted differently than the five regular numbers (chosen from a separate pool of 25 balls versus 70 for regular numbers), making it the only sole match that produces a payout. So while the $2 prize for matching just the Mega Ball is technically a win, it's a break-even outcome since it equals the cost of a ticket.